Peptides

Aureobasidin A is a cyclic depsipeptide that has been found in A. pullulans and has diverse biological activities. It inhibits inositol phosphorylceramide synthase, an enzyme involved in sphingolipid biosynthesis (Kis = 0.18 and 0.23 for the C. albicans and S. cerevisiae enzymes, respectively). Aureobasidin A also...

Retatrutide is a triple agonist of the glucagon receptor (GCGR), glucagon-like peptide 1 receptor (GLP-1R), and gastric inhibitory polypeptide receptor (GIP receptor), also known as the glucose-dependent insulinotropic polypeptide receptor. It induces cAMP accumulation in HEK293 cells expressing the human GCGR,...

PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin (Cay-36762). It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the...

[Asp371]-Tyrosinase (369-377) is a naturally occurring tyrosinase antigen peptide. It is formed via post-translational modification of Asn371. [Asp371]-Tyrosinase (369-377) binds to MHC class I subtype HLA-A*0201-positive T2 cells (IC50 = 1.2 µg/ml) and induces lysis of HLA-A2.1-positive T2 cells incubated with...

Synthetic Strep-tag(R)II peptide recognized by Strep-Tactin(R), Strep-Tactin(R)XT as well as the monoclonal antibodies, StrepMAB-Classic and StrepMAB-Immo. It can be used for competitive elution of Strep-tag(R)II fusion proteins or as control protein in dot blot assays.

N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fNLFNYK) is a synthetic chemotactic peptide. It binds to the formyl peptide receptor (FPR, Kd = 2.2 nM). fNLFNYK has been conjugated to various fluorophores to monitor FPR internalization.Formal Name: N-formyl-L-norleucyl-L-leucyl-L-phenylalanyl-L-norleucyl-L-tyrosyl-L-lysine,...

Atogepant is an antagonist of the calcitonin gene-related peptide (CGRP) receptor (IC50 = 0.026 nM). It is selective for the CGRP receptor over the adrenomedullin receptors (AM1) and AM2, calcitonin (CT) receptor, amylin receptor 1 (AMY1), and AMY3 receptor (IC50s = >18,000, 400, 6,274, 2.4 and 1,418 nM,...

KEMPFPKYPVEP Peptide is a peptide fragment of the dairy protein beta-casein. It can be produced by the protease M from A. oryzae and is found in dairy products fermented by fungi but not bacteria. KEMPFPKYPVEP Peptide (2 mg/kg) increases the levels of dopamine, norepinephrine, and homovanillic acid, but not...

Bradykinin (2-9) is a metabolite of the endogenous vasodilator peptide bradykinin (Cay-37408). It is formed from bradykinin via N-terminal cleavage by carboxypeptidase.Synonyms: BK (2-9), (Des-Arg1)-BK, (Des-Arg1)-Bradykinin, H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Molecular Formula: C44H61N11O10 . XCF3COOH. Formula...

Heparin-binding peptide is a synthetic peptide fragment corresponding to residues 1,892-1,899 of the C-terminal heparin-binding domain of fibronectin. It induces focal adhesion formation in pre-spread human embryonic fibroblasts (HEFs) when used at concentrations ranging from 1 to 1,000 µg/ml. Heparin-binding...

Kassinin is a tachykinin neuropeptide and agonist of the neurokinin-2 (NK2) and NK3 receptors. It is selective for the NK2 and NK3 receptors over the NK1 receptor. Kassinin (1 µM) increases the short-circuit current in isolated frog skin. It induces contractions in isolated guinea pig ileum and isolated rabbit...

Buccalin A is a neuropeptide that is found in gastropod motor neurons and is involved in neuromuscular signaling. It reduces current-induced muscle contraction amplitude but not muscle relaxation rate in isolated and washed A. californica accessory radula closer (ARC) muscle fibers when used at a concentration of 10...