Peptides

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(Z-LLE)2R110
(Z-LLE)2R110

Item number: ABD-13466

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
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(Ac-WLA)2R110
(Ac-WLA)2R110

Item number: ABD-13468

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
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Bortezomib
Bortezomib

Item number: Cay10008822-1

Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
Keywords: LDP-341, MG-341, MLN341, NSC 681239, PS-341, Velcade,...
Application: Proteasome subunit beta type-1/5 inhibitor
CAS 179324-69-7
MW: 384.2 D
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Gly-Phe-beta-naphthylamide
Gly-Phe-beta-naphthylamide

Item number: Cay14634-100

Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases...
Keywords: H-Gly-Phe-BNA, glycyl-N-2-naphthalenyl-L-phenylalaninamide
Application: Cathepsin C substrate
CAS 21438-66-4
MW: 347.4 D
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L-Leucyl-L-Leucine methyl ester (hydrochloride)
L-Leucyl-L-Leucine methyl ester (hydrochloride)

Item number: Cay16008-1

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid...
Keywords: LLME, LLOMe, L-leucyl-L-leucine, methyl ester, monohydrochloride
Application: Specific cytotoxin
CAS 6491-83-4
MW: 294.8 D
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Peptide YY (3-36)
Peptide YY (3-36)

Item number: Cay16502-1

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite. PYY, along with neuropeptide Y (NPY, Cay-15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate...
Keywords: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine
Application: Building block, Click Chemistry
CAS 126339-09-1
MW: 4049.5 D
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Glucagon
Glucagon

Item number: Cay24204-1

Glucagon is a peptide hormone produced from proglucagon in pancreatic alpha cells that has a role in the regulation of glucose metabolism. Pulsatile application of glucagon to rat hepatocytes stimulates glucose production ex vivo. It also stimulates glucose output from perfused rat livers via increases in...
Keywords: glucagon (swine)
Origin: Swine
CAS 16941-32-5
MW: 3482.8 D
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MeOSuc-AAPV-pNA
MeOSuc-AAPV-pNA

Item number: Cay17601-10

Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to...
Keywords: N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide
Application: Neutrophil elastase & PR3 substrate
CAS 70967-90-7
MW: 590.6 D
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Maltose Binding Protein (MBP) Control
Maltose Binding Protein (MBP) Control

Item number: 000-001-385-1

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Z-VAD(OMe)-FMK
Z-VAD(OMe)-FMK

Item number: Cay14463-1

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in...
Keywords: Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone,...
Application: Caspase inhibitor
CAS 187389-52-2
MW: 467.5 D
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Orexin A (bovine, human, mouse, rat)
Orexin A (bovine, human, mouse, rat)

Item number: Cay15073-500

Orexin A is a 33 amino acid hypothalamic neuropeptide with a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It...
Keywords: Hypocretin-1, Hcrt1
Application: HCRTR1/2 Ox1R / Ox2R ligand
CAS 205640-90-0
MW: 3561.1 D
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3,3',5'-Triiodo-L-thyronine
3,3',5'-Triiodo-L-thyronine

Item number: Cay17598-25

3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...
Keywords: 3,3',5'-T3, Reverse T3, rT3, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
Application: TR Delta alpha1 activator
CAS 5817-39-0
MW: 651 D
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