May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. (www.uniprot.org) Human Leptin produced syntheticaly contains 35 amino acids (fragment 22-56) having a molecular mass of 3950.6 Dalton. A 16kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.
|Keywords:||OB Protein, Obesity Protein, OBS, Obesity factor, Leptin|
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