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VEGF-A is a member of the PDGF/VEGF family of growth factors that regulates development,... more
Product information "VEGF-A 164 variant (mouse, recombinant)"
VEGF-A is a member of the PDGF/VEGF family of growth factors that regulates development, proliferation, and maintenance of the vascular system. Alternative splicing of Vegfa pre-mRNA leads to the formation of VEGF-A 164 variant (VEGF-164), an isoform of VEGF-A that contains two heparin binding domains that interact with VEGFR1 and VEGFR2, the VEGFR co-receptors neuropilin-1 (NRP1) and NRP2, and matrix-associated glycosaminoglycans. VEGF-164 exists as a secreted or matrix-bound homodimer and is expressed in the brain, bone, eye, heart, lung, kidney and liver. Transgenic overexpression of VEGF-164 in the podocytes of mice induces complete collapse of the glomerular capillary network and is perinatal lethal. Inhibition of VEGF-164 with a neutralizing aptamer inhibits leukocyte adhesion and neovascularization in the retina in a rat model of hyperoxia-induced proliferative retinopathy. Serum levels of the human homolog VEGF-165 are increased in patients with melanoma and positively correlated with metastasis. VEGF-165 levels are also increased in the serum, synovial fluid, and inflamed joints of patients with rheumatoid arthritis. Cayman's VEGF-A 164 variant (mouse, recombinant) protein can be used for cell-based assay applications. This protein consists of 164 amino acids, has a calculated molecular weight of 19.4 kDa, and a predicted N-terminus of Ala27 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the molecular weight of the protein is 24 kDa due to apparent post-translational modifications.Synonyms: Vascular Endothelial Growth Factor A 164 variant. Purity: >90% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant mouse VEGF-A 164 variant expressed in insect cells (baculovirus). Amino Acids: 27-190. MW: 19.4 kDa. Formulation: (Request formulation change), Lyophilized from sterile 20 mM HAC-sodium acetate, pH 6.5, with 500 mM sodium chloride. UniProt Accession #: Q00731-2.
Keywords: | VPF, VPF, Vegf, Vegfa, VEGF-A, VEGF-A, Vascular permeability factor, Vascular permeability factor, Vascular endothelial growth factor A, Vascular endothelial growth factor A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32068 |
Properties
Conjugate: | No |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K05448 | Matching products |
UniProt ID : | Q00731 | Matching products |
Gene ID | GeneID 22339 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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