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Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. (www.uniprot.org) Produced in E.coli. Homodimer, polypeptide chain containing 2 x 121 amino acids.
Keywords: | Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGF, MGC70609 |
Supplier: | Biomol GmbH |
Supplier-Nr: | 52625.1 |
Properties
Application: | Cell Culture |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Human |
MW: | 28423 D |
Purity: | >95% |
Database Information
KEGG ID : | K05448 | Find alternatives |
UniProt ID : | P15692 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |