Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)

Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97288.5 5 µg - -

3 - 10 business days*

70.00€
97288.20 20 µg - -

3 - 10 business days*

180.00€
97288.1 1 mg - -

3 - 10 business days*

-
 
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for... more
Product information "Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)"

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. (www.uniprot.org) Human recombinant TNFR2 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids fragment (23-206) having a molecular weight of 25kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. TNFR2 belongs to the TNF-receptor superfamily. TNFR2 is receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFR2 mediates the majority of the metabolic effects of TNF-alpha. In addition, knockout studies in mice propose a role for TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2 expression might have a significant role in the angiogenesis, tumor cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast.

Keywords: Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, CD120b, Etanercept, TNF-R2, TNF-RII, TNFR-II, TNFRSF1B, TNFBR, TNFR2, TBPII, TNFR2, TNFR1B, TNFR80
Supplier: Biomol GmbH
Supplier-Nr: 97288

Properties

Application: Bioassay
Conjugate: No
Expressed in: E.coli
Origin: Human
Purity: >95%
Format: Purified

Database Information

KEGG ID : K05141 | Find alternatives
UniProt ID : P20333 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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