Tumor Necrosis Factor Receptor Superfamily Member 11B, active (TNFRSF11B), Recombinant, Human

Tumor Necrosis Factor Receptor Superfamily Member 11B, active (TNFRSF11B), Recombinant, Human
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
348254.10 10 µg - -

1 - 19 business days

-
348254.100 100 µg - -

1 - 19 business days

-
348254.50 50 µg - -

1 - 19 business days

-
348254.250 250 µg - -

1 - 19 business days

-
 
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in... more
Product information "Tumor Necrosis Factor Receptor Superfamily Member 11B, active (TNFRSF11B), Recombinant, Human"
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is <10ng/ml, corresponding to a specific activity of ?1x10e5IU/mg in the presence of 10ng/mL soluble rHuRANKL (sRANKL). Sequence: ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQKCGIDVTL EPKSSDKTHT CPPCPAPEFE GAPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPTPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK, Molecular Weight: 109.6kD, PubMed ID: 9108485, 9492069, 9688283, 14702039, 16421571, 15489334, 9571159, 15340161, 12110935, 9168977, 9603945, 9478964, 11505389, 22664871, 12189164, Gene Name: TNFRSF11B, OCIF, OPG, Swiss Prot: O00300, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: OCIF, TNFRSF11B, Osteoprotegerin, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B
Supplier: United States Biological
Supplier-Nr: 348254

Properties

Conjugate: No
MW: 109,6
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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