Transforming Growth Factor ß-2/TGFß2/TGFB2 Protein (recombinant mouse)

Protein Construction: Recombinant Mouse Transforming Growth Factor beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed. Sequence: Ala303-Ser414. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 25-28 kDa. Protein function: Transforming growth factor beta 2 (TGF-ß2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-ß2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-ß isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-ß receptor type II (TßR-II), and a TGF-ß receptor type I (TßR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-ß expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. Protein function: Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. [The UniProt Consortium]