Transforming Growth Factor Beta-1/TGFB1 (recombinant human)

Transforming Growth Factor Beta-1/TGFB1 (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH033947.10 10 µg -

7 - 16 business days*

184.00€
E-PKSH033947.50 50 µg -

7 - 16 business days*

548.00€
 
Protein Construction: Recombinant Human Transforming Growth Factor beta 1 is produced by our... more
Product information "Transforming Growth Factor Beta-1/TGFB1 (recombinant human)"
Protein Construction: Recombinant Human Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Leu30-Arg278(Cys33Ser) is expressed. Sequence: Leu30-Arg278(Cys33Ser). Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 20-30 kDa. Protein function: Transforming Growth Factor beta-1 (TGFbeta-1) is a secreted protein which belongs to the TGF-beta family. TGFbeta-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFbeta-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFbeta-1 peptide.Disulfide-linked homodimers of LAP and TGF-beta 1 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP is also capable of associating with active TGF-beta with high affinity, and can neutralize TGF-beta activity. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins. Although different isoforms of TGF-beta are naturally associated with their own distinct LAPs, the TGF-beta 1 LAP is capable of complexing with, and inactivating, all other human TGF-beta isoforms and those of most other species. Mutations within the LAP are associated with Camurati-Engelmann disease, a rare sclerosing bone dysplasia characterized by inappropriate presence of active TGF-beta 1. Protein function: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. [The UniProt Consortium]
Keywords: TGFB, Recombinant Human Transforming Growth Factor Beta-1/TGFB1
Supplier: Elabscience
Supplier-Nr: E-PKSH033947

Properties

Conjugate: No
Host: Human cells
Species reactivity: human
MW: 28.5 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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