
Request Pricing
Bigger quantity required? Request Bulk
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase (By similarity). (www.uniprot.org) Produced in E.coli as a non-glycosylated, polypeptide chain containing 72 amino acids. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development.
Keywords: | SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1B, TPAR1, SCYB12, SDF-1b, TLSF-b, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, Thymic lymphoma cell-stimulating factor, TLSF |
Supplier: | Biomol GmbH |
Supplier-Nr: | 94864.1 |
Properties
Application: | Chemoattract. |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Mouse |
MW: | 8513 D |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K10031 | Find alternatives |
UniProt ID : | P40224 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Our products are for laboratory research use only: Not for administration to humans!