Sonic HedgeHog, human recombinant (rHuSHH)

Sonic HedgeHog, human recombinant (rHuSHH)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97290.5 5 µg - -

1 - 10 business days

70.00€
97290.25 25 µg - -

1 - 10 business days

180.00€
97290.1 1 mg - -

1 - 10 business days

-
 
Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to... more
Product information "Sonic HedgeHog, human recombinant (rHuSHH)"

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity). (www.uniprot.org) Human recombinant Sonic HedgeHog produced in E.coli is a single, non-glycosylated polypeptide chain containing 175 amino acids and having a molecular mass of 19,683 Dalton. The Human Sonic Hedgehog is 99% homologous to the mouse gene. Cysteine at position 2 has been substituted with Ile. Recombinant Human Sonic Hedgehog is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. 3 mammalian hedgehog genes (sonic, desert, Indian) share about 60% homology. The Human Sonic Hedgehog is 99% homologous to the mouse gene. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Sonic HedgeHog also regulates another factor, the gli oncogene. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog exhibits both floor plate- and motor neuron-inducing activity. Mutations in a long-range Sonic HedgeHog enhancer located in an intron of the limb region 1 gene result in preaxial polydactyly.

Keywords: SHH, HHG-1, HHG1, Sonic hedgehog protein, TPT, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5
Supplier: Biomol GmbH
Supplier-Nr: 97290.1

Properties

Application: Cell culture
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 19683 D
Purity: >97%
Format: Purified

Database Information

KEGG ID : K11988 | Find alternatives
UniProt ID : Q15465 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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