Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32090-50 | 50 µg | - |
6 - 10 business days* |
233.00€
|
Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth,... more
Product information "Somatotropin Long Isoform (human, recombinant)"
Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth, cellular proliferation and differentiation, muscle and bone anabolism, and lipolysis. Alternative splicing of the GH1 pre-mRNA produces one full-length 22 kDa isoform and a short-length 20 kDa isoform, which has reduced affinity for the somatotropin receptor. Somatotropin contains a central hydrophobic core and a bundle of four alpha-helices that forms two somatotropin receptor binding sites. It is synthesized and stored by somatotrophs in the anterior pituitary gland and is secreted episodically as a monomer or dimer in a circadian rhythm that peaks during night sleep. Somatotropin production is induced by stimulation with growth hormone-releasing hormone, ghrelin, or sex steroids and inhibited by somatostatin, IGF-1, or glucocorticoid stimulation. Binding of somatotropin to the somatotropin receptor, which is ubiquitously expressed, activates a variety of intracellular signal transduction pathways, including JAK-STAT, that lead to IGF-1, MAPK, PPARgamma (Cay-61700), or SIRPalpha signaling. Decreased serum levels of somatotropin have been found in patients with dwarfism. Increased somatotropin serum levels have been found in patients with acromegaly, a condition characterized by abnormal bone growth, and are positively correlated with early mortality. Cayman's Somatotropin Long Isoform (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 212 amino acids and has a calculated molecular weight of 24.7 kDa.Synonyms: Growth Hormone 1, Pituitary Growth Hormone. Purity: >85% as determined by SDS-PAGE. Source: Recombinant human N-terminal His-tagged somatotropin expressed in E. coli. Amino Acids: 27-217. MW: 24.7 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P01241.
Keywords: | GH, GH, GH1, GH-N, GH-N, Somatotropin, Somatotropin, Growth hormone, Growth hormone, Growth hormone 1, Growth hormone 1, Pituitary growth hormone, Pituitary growth hormone |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32090 |
Properties
Conjugate: | No |
Purity: | >85% as determined by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K05438 | Matching products |
UniProt ID : | P01241 | Matching products |
Gene ID | GeneID 2688 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed