Somatotropin Long Isoform (human, recombinant)

Somatotropin Long Isoform (human, recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay32090-50 50 µg -

6 - 10 business days*

233.00€
 
Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth,... more
Product information "Somatotropin Long Isoform (human, recombinant)"
Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth, cellular proliferation and differentiation, muscle and bone anabolism, and lipolysis. Alternative splicing of the GH1 pre-mRNA produces one full-length 22 kDa isoform and a short-length 20 kDa isoform, which has reduced affinity for the somatotropin receptor. Somatotropin contains a central hydrophobic core and a bundle of four alpha-helices that forms two somatotropin receptor binding sites. It is synthesized and stored by somatotrophs in the anterior pituitary gland and is secreted episodically as a monomer or dimer in a circadian rhythm that peaks during night sleep. Somatotropin production is induced by stimulation with growth hormone-releasing hormone, ghrelin, or sex steroids and inhibited by somatostatin, IGF-1, or glucocorticoid stimulation. Binding of somatotropin to the somatotropin receptor, which is ubiquitously expressed, activates a variety of intracellular signal transduction pathways, including JAK-STAT, that lead to IGF-1, MAPK, PPARgamma (Cay-61700), or SIRPalpha signaling. Decreased serum levels of somatotropin have been found in patients with dwarfism. Increased somatotropin serum levels have been found in patients with acromegaly, a condition characterized by abnormal bone growth, and are positively correlated with early mortality. Cayman's Somatotropin Long Isoform (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 212 amino acids and has a calculated molecular weight of 24.7 kDa.Synonyms: Growth Hormone 1, Pituitary Growth Hormone. Purity: >85% as determined by SDS-PAGE. Source: Recombinant human N-terminal His-tagged somatotropin expressed in E. coli. Amino Acids: 27-217. MW: 24.7 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P01241.
Keywords: GH, GH, GH1, GH-N, GH-N, Somatotropin, Somatotropin, Growth hormone, Growth hormone, Growth hormone 1, Growth hormone 1, Pituitary growth hormone, Pituitary growth hormone
Supplier: Cayman Chemical
Supplier-Nr: 32090

Properties

Conjugate: No
Purity: >85% as determined by SDS-PAGE
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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