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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033042.10 | 10 µg | - |
7 - 16 business days* |
152.00€
|
|||
E-PKSH033042.50 | 50 µg | - |
7 - 16 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human Serine Protease Inhibitor-clade F1 is produced by our... more
Product information "Serpin F1/PEDF Protein(C-6His) (recombinant human)"
Protein Construction: Recombinant Human Serine Protease Inhibitor-clade F1 is produced by our Mammalian expression system and the target gene encoding Gln20-Pro418 is expressed with a 6His tag at the C-terminus. Sequence: Gln20-Pro418. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 50 kDa. Protein function: Serpin F1 is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins. Serpin F1 is a new promising approach for the treatment of osteosarcoma and has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy. Protein function: Neurotrophic protein, induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. [The UniProt Consortium]
Keywords: | PEDF, PIG35, EPC-1, SERPINF1, Serpin F1, Pigment epithelium-derived factor, Cell proliferation-inducing gene 35 protein, Recombinant Human Serpin F1/PEDF Protein(C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033042 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 45.4 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K19614 | Matching products |
UniProt ID : | P36955 | Matching products |
Gene ID | GeneID 5176 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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