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Product information "Proheparin-Binding EGF-like Growth Factor, mouse recombinant (rmHB-EGF)"
Mouse recombinant HB-EGF produced in E.coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids (63-148) and having a molecular mass of 9.8 kDa. HB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGF's ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.