Human recombinant PDGFRA produced in E.coli is a single, non-glycosylated polypeptide chain containing 522 amino acids (24-524) and having a molecular mass of 58.4 kDa. The PDGFRA is fused to a 20 amino acid His-Tag at N-terminus. PDGFRa is a cell surface tyrosine kinase receptor for PDGF family members. PDGFRa binds to both A and B subunits of PDGF. It is known that PDGFRa is vital for kidney development since mice heterozygous for the receptor display defective kidney phenotypes.
|Keywords:||Platelet-derived growth factor receptor alpha polypeptide, PDGFR2, PDGF-R-alpha, CD140 antigen-like family member A, CD140a antigen, alpha-type platelet-derived growth factor receptor, RHEPDGFRA, rearranged-in-hypereosinophilia-platelet derived growth fac|
|KEGG ID :||K04363 | Find alternatives|
|UniProt ID :||P16234 | Find alternatives|
|Gene ID||GeneID 5156 | Find alternatives|
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