Product information "Osteoprotegerin, His Tag, Hi-5, human recombinant (rHuOPG-His)"
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. (www.uniprot.org) Produced in baculovirus as a single, glycosylated, polypeptide chain containing 398 amino acids (fragment 22-401). The Osteoprotegerin is fused to 17 amino acid His Tag at C-terminus.