Recombinant human Myostatin contains a 6-His-tag at the N-terminal end, is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product contains no animalderived components or impurities. The biological activity of Myostatin is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells. Myostatin (GDF8, MSTN) belongs to the transforming growth factor beta (TGFBs) superfamily, which includes : TGF betas, the bone morphogenetic protein (BMPs), growth differentiation factors (GDFs), activins and inhibins. As other members of this superfamily, is synthesized and secreted as a homodimeric prepropeptide that is cleaved by proprotein convertases such as furin to generate the dimeric N- terminal propeptide and the dimeric C-terminal mature active protein.Myostatin is one of the most important protein that controls myoblast proliferation and it is a potent negative regulator of skeletal muscle mass in a number of animal species. Several studies have shown that Myostatin could play an important role in cardiac development and physiology.Genetic deletion of Myostatin or in vivo administration of the Myostatin propeptide induces muscle hypertrophy as well as enhanced glucose utilization and insulin sensitivity and a reduction in overall fat mass.
|Keywords:||GDF8, MSTN, GDF-8, Myostatin, Growth/differentiation factor 8|
|Application:||Cell culture, WB|
|KEGG ID :||K05497 | Find alternatives|
|UniProt ID :||O14793 | Find alternatives|
|Gene ID||GeneID 2660 | Find alternatives|
Handling & Safety
|Shipping:||+4°C (International: +4°C)|
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