Myostatin, active, His Tag, human recombinant (rHuMyostatin-His), plant based, bio-clean

Myostatin, active, His Tag, human recombinant (rHuMyostatin-His), plant based, bio-clean
Item number Size Datasheet Manual SDS Delivery time Quantity Price
99863.5 5 µg - -

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123.00€
 
Recombinant human Myostatin contains a 6-His-tag at the N-terminal end, is produced by transient... more
Product information "Myostatin, active, His Tag, human recombinant (rHuMyostatin-His), plant based, bio-clean"

Recombinant human Myostatin contains a 6-His-tag at the N-terminal end, is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product contains no animalderived components or impurities. The biological activity of Myostatin is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells. Myostatin (GDF8, MSTN) belongs to the transforming growth factor beta (TGFBs) superfamily, which includes : TGF betas, the bone morphogenetic protein (BMPs), growth differentiation factors (GDFs), activins and inhibins. As other members of this superfamily, is synthesized and secreted as a homodimeric prepropeptide that is cleaved by proprotein convertases such as furin to generate the dimeric N- terminal propeptide and the dimeric C-terminal mature active protein.Myostatin is one of the most important protein that controls myoblast proliferation and it is a potent negative regulator of skeletal muscle mass in a number of animal species. Several studies have shown that Myostatin could play an important role in cardiac development and physiology.Genetic deletion of Myostatin or in vivo administration of the Myostatin propeptide induces muscle hypertrophy as well as enhanced glucose utilization and insulin sensitivity and a reduction in overall fat mass.

Keywords: GDF8, MSTN, GDF-8, Myostatin, Growth/differentiation factor 8
Supplier: Biomol GmbH
Supplier-Nr: 99863

Properties

Application: Cell culture, WB
Conjugate: No
Expressed in: Nicotiana
Origin: Human
MW: 24,8 kD
Purity: >97%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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