Mucosae-Associated Epithelial Chemokine (CCL28), human recombinant (rHuMEC)

Mucosae-Associated Epithelial Chemokine (CCL28), human recombinant (rHuMEC)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97342.5 5 µg - -

3 - 10 business days*

71.00€
97342.20 20 µg - -

3 - 10 business days*

184.00€
97342.1 1 mg - -

3 - 10 business days*

-
 
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and... more
Product information "Mucosae-Associated Epithelial Chemokine (CCL28), human recombinant (rHuMEC)"

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. (www.uniprot.org) Recombinant human CCL28 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids and having a molecular mass of 12.3 kDa. CCL28 is part of the subfamily of small cytokine CC genes. CCL28 shows chemotactic activity for resting CD4 or CD8 T cells and eosinophils. CCL28 binds to chemokine receptors CCR3 and CCR10. CCL28 is involved in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28 is involved in the pathogenesis of inflammatory skin diseases. Human CCL28 cDNA encodes a 127 amino acid residue precursor protein with a putative 22 amino acid residue signal peptide that is cleaved to produce the 105 amino acid residue mature protein. Human and mouse CCL28 are highly conserved, sharing 83% amino acid identity in their mature regions. CCL28 shares the most homology with CCL27/CTACK. Human and mouse CCL28 RNA expression was found to be highest in normal and pathologic colon with the protein being expressed by epithelial cells. Human CCL28 RNA was also present in normal and asthmatic lung tissues.

Keywords: MEC, CCK1, SCYA28, MGC71902, CCL28, C-C motif chemokine 28, Small-inducible cytokine A28, Mucosae-associated epithelial chemokine, Protein CCK1
Supplier: Biomol GmbH
Supplier-Nr: 97342.1

Properties

Application: Cell culture
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 12300 D
Purity: >97%
Format: Purified

Database Information

KEGG ID : K05513 | Find alternatives
UniProt ID : Q9NRJ3 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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