MIF (human recombinant)

MIF (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14493-100 100 µg -

1 - 10 business days

263.00€
 
Macrophage Migration Inhibitory Factor (MIF) is a small, pro-inflammatory cytokine. MIF signaling... more
Product information "MIF (human recombinant)"
Macrophage Migration Inhibitory Factor (MIF) is a small, pro-inflammatory cytokine. MIF signaling is important in septic shock, arthritis, colitis, and cardiovascular diseases. MIF counteracts glucocorticoid signaling, which would otherwise inhibit inflammation. Secreted MIF binds to CD74 receptors, which then couple to CD44, during monocyte recruitment. In addition to CD44 binding, MIF is an enzymatically active keto-enol tautomerase that is inhibited by isothiocyanates such as sulforaphane. Overexpression of MIF has been seen in several cancers. MIF overexpression has been shown to promote hypoxia induced HIF-1alpha stabilization leading to changes in the tumor microenvironment, including stimulation of angiogenesis and neovascularization.
Keywords: GIF, MIF, GLIF, EC=5.3.2.1, EC=5.3.3.12, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase, Glycosylation-inhibiting factor, Macrophage migration inhibitory factor
Supplier-Nr: 14493-100

Properties

Application: Enzyme activity, WB
Purity: >95% estimated by SDS-PAGE
Format: Purified

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+P351+P338, P332+P313, P337+P313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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