LIF, Recombinant, Human (Leukemia Inhibitory Factor, hLIF)

LIF, Recombinant, Human (Leukemia Inhibitory Factor, hLIF)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
137462.10 10 µg - -

3 - 19 business days*

454.00€
 
Leukemia Inhibitory Factor (LIF) is a 20 kDa pleiotrophic factor belonging to the IL-6... more
Product information "LIF, Recombinant, Human (Leukemia Inhibitory Factor, hLIF)"
Leukemia Inhibitory Factor (LIF) is a 20 kDa pleiotrophic factor belonging to the IL-6 superfamily of cytokines (1). LIF is expressed in a number of tissues and cell types. The LIF receptor is a heterodimer comprised of LIF-R (gp190) and gp130, a common signal transducer for IL-6-type cytokines (1). Depending on cell type and context, LIF/LIF-R can activate Erk, PI3K, and Jak1/Stat1/3 pathways (1,2). LIF has a diverse array of biological activities. Murine embryonic stem cells are dependent on LIF for pluripotency and self-renewal in vitro (1). Exercise- induced LIF secretion in muscle induces myoblast proliferation, suggesting that LIF may play a role in exercise-induced muscle hypertrophy (2). LIF also negatively regulates Th2 and Th17 cell differentiation (3,4). Source: Recombinant protein corresponding to human LIF, expressed in E. coli. Molecular Weight: ~20kD, Biological Activity: Determined in a TF-1 cell proliferation assay. The ED50 of each lot is 0.2-1.5ng/ml. Endotoxin: <0.01ng/1ug, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: 137462

Properties

Conjugate: No
Format: Highly Purified

Database Information

UniProt ID : P15018 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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