LIF (human) (rec.) (His)

LIF (human) (rec.) (His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-201LIF-C010 10 µg - -

3 - 9 business days*

CHI-HF-201LIF-C050 50 µg - -

3 - 9 business days*

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also... more
Product information "LIF (human) (rec.) (His)"
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.
Keywords: LIF, MLPLI, HILDA, D factor, Emfilermin, Leukemia inhibitory factor, Melanoma-derived LPL inhibitor, Differentiation-stimulating factor, Leukemia Inhibitory Factor, Differentiation-stimulating Factor, D Factor, Melanoma-derived LPL Inhibitor, MLPLI, HILDA
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-201LIF


Application: Bioassays
Conjugate: No
Expressed in: Human cells
Origin: Human
MW: ~35 kD
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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