Interleukin 7 Receptor alpha, Mouse IgG2a Fc Fusion Protein (Interleukin-7 Receptor Subunit alpha, I

CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2Rg) to form a high affinity IL-7 receptor (1). CD127 engagement is necessary for T cell development in humans (2). Molecular Structure: A soluble molecule consisting of murine CD8 alpha signal peptide residual amino acids and linker, the mature extracellular domain of human CD127 (IL-7Ra) and murine IgG2a Fc + hinge regions (464 aa total). The molecule is dimeric with a predicted monomeric non glycosylated molecular weight of 52.8kD. , Applications:, Suitable for use in ELISA and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.