Interleukin 4, Recombinant, Mouse (Interleukin-4, IL-4, IL4, B Cell Stimulatory Factor 1, BSF-1, Lym

Interleukin 4, Recombinant, Mouse (Interleukin-4, IL-4, IL4, B Cell Stimulatory Factor 1, BSF-1, Lym
Item number Size Datasheet Manual SDS Delivery time Quantity Price
I8426-33Q.10 10 µg - -

1 - 19 business days

454.00€
 
IL-4 is produced by T cells, NK T cells, gamma delta cells, and mast cells (1). Target cells... more
Product information "Interleukin 4, Recombinant, Mouse (Interleukin-4, IL-4, IL4, B Cell Stimulatory Factor 1, BSF-1, Lym"
IL-4 is produced by T cells, NK T cells, gamma delta cells, and mast cells (1). Target cells include B cells, T cells, and macrophages (1). IL-4 induces the polarization of naïve helper T cells into the TH2 phenotype (1,2). IL-4 also promotes B cell proliferation, antibody class switching and the production other TH2 cytokines including IL-5 and IL-9. IL-4 induced TH2 polarization is important in developing humoral immunity against extracellular pathogens (1) and is involved in the development of allergy and asthma (3). IL-4 binds to two distinct receptors, the Type I receptor and Type II receptor. Type I receptor is a heterodimer consisting of IL-4Ra chain and the common gamma chain, gc (4,5). Type II receptor, which is shared with IL-13, is a heterodimer of IL-4Ra and IL-13Ra1. Signaling initiated via Type I receptor results in the activation of Jak1/Stat6, Jak3 and the PI3K/Akt pathways (4). The Type II receptor activates the Jak1/Stat6 and the Tyk2/Stat3 pathways (4). Source: Recombinant corresponding to aa21-140 (His21-Ser140) of mouse IL-4 expressed in human 293 cells (NP_067258). Bioactivity: Determined in an HT-2 cell proliferation assay. The ED50 is 100-400pg/ml. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: I8426-33Q

Properties

Application: WB
Conjugate: No
Format: Purified

Database Information

UniProt ID : P07750 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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