Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
348132.10 | 10 µg | - | - |
3 - 19 business days* |
552.00€
|
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Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 10e3 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. {ECO:0000269, PubMed:16646978, ECO:0000269, PubMed:20300079, ECO:0000269, PubMed:21242515, ECO:0000269, PubMed:21881584, ECO:0000269, PubMed:21965679, ECO:0000269, PubMed:24829417}. Biological Activity: Fully biologically active when compared to standard. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36beta at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL. Sequence: MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE, Molecular Weight: 17.7kDa, PubMed ID: 10744718, 10625660, 11991722, 15815621, 15489334, 16646978, 20300079, 21965679, 21242515, 21881584, 24829417, Gene Name: IL36B,IL1F8,IL1H2, Swiss Prot: Q9NZH7, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | IL1F8, IL36B, IL-1F8, IL-1H2, FIL1 eta, IL-1 eta, Interleukin-1 eta, Interleukin-36 beta, Interleukin-1 homolog 2, Interleukin-1 family member 8 |
Supplier: | United States Biological |
Supplier-Nr: | 348132 |
Properties
Conjugate: | No |
MW: | 17,7 |
Format: | Highly Purified |
Database Information
KEGG ID : | K05486 | Matching products |
UniProt ID : | Q9NZH7 | Matching products |
Gene ID | GeneID 27177 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Our products are for laboratory research use only: Not for administration to humans!