Interleukin-33, His Tag, human recombinant (rHuIL-33-His)

Interleukin-33, His Tag, human recombinant (rHuIL-33-His)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97281.2 2 µg - -

3 - 10 business days*

70.00€
97281.10 10 µg - -

3 - 10 business days*

180.00€
97281.1 1 mg - -

3 - 10 business days*

-
 
Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1,... more
Product information "Interleukin-33, His Tag, human recombinant (rHuIL-33-His)"

Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines. (www.uniprot.org) Human recombinant Interleukin-33 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 159 amino acids C-terminal fragment (112-270) having a molecular weight of 20.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. Interleukin-33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T-cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

Keywords: IL33, Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, Interleukin-1 family member 11, IL- 1F11, Nuclear factor from high endothelial venules, NFEHEV, DKFZp586H0523, RP11-575C20.2, IL-33
Supplier: Biomol GmbH
Supplier-Nr: 97281

Properties

Application: Bioassay
Conjugate: No
Expressed in: E.coli
Origin: Human
Purity: >95%
Format: Purified

Database Information

KEGG ID : K12967 | Find alternatives
UniProt ID : O95760 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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