Interleukin-28A, HEK, human recombinant (rHuIL-28A-HEK)

Interleukin-28A, HEK, human recombinant (rHuIL-28A-HEK)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97504.2 2 µg - -

3 - 10 business days*

70.00€
97504.10 10 µg - -

3 - 10 business days*

180.00€
97504.1 1 mg - -

3 - 10 business days*

-
 
Human recombinant Interleukin-28A produced in HEK cells is a non-glycosylated monomer, having a... more
Product information "Interleukin-28A, HEK, human recombinant (rHuIL-28A-HEK)"

Human recombinant Interleukin-28A produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity. IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19. IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.

Keywords: Interleukin-28A, IL-28A, IFN-Lambda 2, Interferon-Lambda 2, Cytokine ZCYTO20, IL28A, IFNL2, ZCYTO20.
Supplier: Biomol GmbH
Supplier-Nr: 97504

Properties

Application: Cell Culture
Conjugate: No
Expressed in: Human cells
Origin: Human
MW: 24000 D
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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