Interleukin-22 (IL-22, CRF2Ð9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor), human reco

Interleukin-22 (IL-22) is a regulatory cytokine and member of the IL-10 family, secreted by activated T cells, which signals through a class II cytokine receptor system consisting of IL-22R and IL-10R-beta/CRF2-4. IL-22 has been shown to act as an inhibitor of the production of IL-4 by Th2 cells, up-regulate the production of acute phase reactants in the pancreas and liver, and to be up-regulated in intestinal inflammation associated with Crohn's disease. Source: E. coli, Applications: Suitable for use in Functional Assays. Other applications not tested. Biological Activity: Determined by its ability to activate STAT following receptor ligand interaction. Endotoxin: <1EU/ug , Molecular Weight: 33.6kD (146 amino acid homodimer), Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.