Interleukin-17A/F Heterodimer/IL-17A & IL-17F Protein(C-6His) (recombinant human)

Interleukin-17A/F Heterodimer/IL-17A & IL-17F Protein(C-6His) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH032619.10 10 µg -

7 - 16 business days*

212.00€
E-PKSH032619.50 50 µg -

7 - 16 business days*

622.00€
 
Activity: Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast... more
Product information "Interleukin-17A/F Heterodimer/IL-17A & IL-17F Protein(C-6His) (recombinant human)"
Activity: Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells.The ED50 for this effect is typically 0.2 ng/mL. Protein Construction: Recombinant Human Interleukin-17A/Interleukin-17F Heterodimer is produced by our Mammalian expression system and the target gene encoding Ile20-Ala155&Arg31-Gln163 is expressed with a 6His tag at the C-terminus. Sequence: Ile20-Ala155&Arg31-Gln163. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 15-18 kDa. Protein function: The IL-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. The family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. All members of the IL-17 family have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape, yet they have no sequence similarity to any other known cytokines. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. Protein function: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). [The UniProt Consortium]
Keywords: IL-17, IL17A, CTLA8, CTLA-8, IL-17A, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, Recombinant Human Interleukin-17A/F Heterodimer/IL-17A & IL-17F Protein(C-6His)
Supplier: Elabscience
Supplier-Nr: E-PKSH032619

Properties

Conjugate: No
Host: Human cells
Species reactivity: human
MW: 43.2 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: +4°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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