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Human recombinant Interleukin-10 produced in HEK cells is a glycosylated non-disulfide bonded... more
Product information "Interleukin-10, HEK, human recombinant (rHuIL-10-HEK)"
Human recombinant Interleukin-10 produced in HEK cells is a glycosylated non-disulfide bonded homodimer, having a total molecular weight of 17kDa. IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Keywords: | B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor. |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97490.1 |
Properties
Application: | Cell Culture |
Conjugate: | No |
Expressed in: | Human cells |
Origin: | Human |
MW: | 17000 D |
Purity: | >95% |
Format: | Lyophilized |
Database Information
KEGG ID : | K05443 | Find alternatives |
UniProt ID : | P22301 | Find alternatives |
Gene ID | GeneID 3586 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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