Interferon a2A Variant Protein(Lys46)/IFN-a2A (recombinant human)

Activity: Measured by a viral resistance assay using VSV-WISH cells.The ED50 for this effect is typically 10 pg/mL. Protein Construction: Recombinant Human Interferon alpha-2a is produced by our E.coli expression system and the target gene encoding Cys24-Glu188 is expressed. Sequence: Cys24-Glu188. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 16 kDa. Protein function: At least 23 different variants of IFN-a are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-a subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-a subtypes only differ in their sequences by one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end. Protein function: Produced by macrophages, IFN-alpha have antiviral activities. [The UniProt Consortium]