IL-35 (human):Fc (human) (rec.)

IL-35 (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-21035-C025 25 µg - -

3 - 9 business days*

286.00€
 
The human IL-35 complex composed of the Ebi3 subunit (aa 21-229) and the IL-12a (p35) subunit (aa... more
Product information "IL-35 (human):Fc (human) (rec.)"
The human IL-35 complex composed of the Ebi3 subunit (aa 21-229) and the IL-12a (p35) subunit (aa 57-253) is fused through a polypeptide linker to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.
Keywords: Interleukin-35, NKSF1, IL12A, IL-12A, CLMF p35, IL-12 subunit p35, Interleukin-12 subunit alpha, NK cell stimulatory factor chain 1, Cytotoxic lymphocyte maturation factor 35 kDa subunit, EBI3, IL27B, IL-27B, IL-27 subunit beta, EBV-induced gene 3 protein
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-21035

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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