Human globular ACRP-30

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-12001-25 25 µg - -

3 - 11 business days*

590.00€
ABE-32-12001-100 100 µg - -

3 - 11 business days*

1,015.00€
 
Source: Genetically modified E.coli. Predicted MW: Monomer, 16.7 kDa (145 aa) The globular... more
Product information "Human globular ACRP-30"
Source: Genetically modified E.coli. Predicted MW: Monomer, 16.7 kDa (145 aa) The globular subunit of adipocyte complement-related protein of 30 kDa (ACRP-30) is a naturally occurring cleavage product of adiponectin, a protein made exclusively by adipocytes. ACRP-30 is an abundant serum protein and plays an important role in hyperglycemia, insulin resistance, and fatty acid oxidation. ACRP-30 signals through adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). Protein function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-12001

Properties

Conjugate: No
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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