Human Fibroblast Growth Factor-acidic (AF)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-12063-50 50 µg - -

3 - 11 business days*

ABE-32-12063-100 100 µg - -

3 - 11 business days*

Source: Genetically modified E.coli. Predicted MW: Monomer, 16 kDa (141 aa) Acidic fibroblast... more
Product information "Human Fibroblast Growth Factor-acidic (AF)"
Source: Genetically modified E.coli. Predicted MW: Monomer, 16 kDa (141 aa) Acidic fibroblast growth factor (FGF-acidic), also known as FGF-1, is a potent inducer of DNA synthesis, cell proliferation, and has chemotactic activities. FGF-acidic regulates cardiogenesis through protein kinase C signaling. FGF-acidic also functions as an insulin sensitizer and mediates adipose tissue remodeling.  High serum levels of FGF-acidic are associated with type 2 diabetes mellitus (T2DM), suggesting a pathogenic role of FGF-acidic during T2DM. Protein function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-12063


Conjugate: No
Format: Lyophilized

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