Recombinant human Granulocyte-macrophage colony-stimulating factor (GM-CSF) contains a 10-His-tag at the N-terminal end, is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product contains no animal-derived components or impurities. The activity of recombinant human GM-CSF is determined by the dose-dependent induction of human TF-1 proliferation cell. GMCSF is a cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. It is involved in differentiation of dendritic cells and is a key factor in differentiation pathways leading form stem cells. GMCSF is produced by several cell types as monocytes, fibroblasts, endothelial cells and T- Lymphocytes in response to a number of inflammatory mediators present in the hemopoietic environment and peripheral site of inflammation. Human GMCF is an important therapeutic cytokine used in the treatment of myeloid leukemia, neutropenia and aplastic anemia and it could become interesting in the treatment following bone marrow transplantation.
|Keywords:||CSF, CSF2, GMCSF, GM-CSF, Molgramostin, Sargramostim, Colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor|
|Application:||Cell culture, WB|
|KEGG ID :||K05427 | Find alternatives|
|UniProt ID :||P04141 | Find alternatives|
|Gene ID||GeneID 1437 | Find alternatives|
Handling & Safety
|Shipping:||+4°C (International: +4°C)|
Our products are for laboratory research use only: Not for administration to humans!