Mouse recombinant EGF produced in E.coli is a single polypeptide chain containing 77 amino acids (977-1029) and having a molecular mass of 8.6kDa. EGF is fused to a 24 amino acid His-tag at N-terminus. Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
|Keywords:||Urogastrone, URG, EGF.|
|KEGG ID :||K04357 | Find alternatives|
|UniProt ID :||P01132 | Find alternatives|
|Gene ID||GeneID 13645 | Find alternatives|
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