Connective Tissue Growth Factor/CTGF/CCN2 Protein (recombinant human)

Protein Construction: Recombinant Human Connective tissue growth factor is produced by our Mammalian expression system and the target gene encoding Glu27-Ala180 is expressed. Sequence: Glu27-Ala180. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 16-18 kDa. Protein function: CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cell adhesion and enhanced cell migration and proliferation. CTGF has also been shown to be essential for epithelial to mesenchymal transition (EMT), a process whereby normal functioning cells morph into ones that produce mainly scar tissue (of which collagen in the major protein component). Protein function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. [The UniProt Consortium]