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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and... more
Product information "CCL5/RANTES (human, recombinant)"
Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and member of the CC subfamily of chemokines. It is composed of an unstructured N-terminal region, a flexible loop, a 310-helix, three strands of an antiparallel beta-sheet, and a single C-terminal alpha helix. It is expressed in T cells, platelets, macrophages, tubular epithelial cells, synovial fibroblasts, and endothelial cells, as well as some tumor cells. It functions as a monomer or various oligomers and interacts with the G protein-coupled receptors (GPCRs) chemokine (C-C motif) receptor 1 (CCR1), CCR3, CCR4, CCR5, and GPR75 to activate cell signaling in an oligomerization state-dependent manner. It also interacts with the non-signaling receptors ACKR1, ACKR2, and CCRL2. CCL5 functions as a chemoattractant of immune cells that predominantly express CCR5, such as activated T cells and monocytes, as well as those expressing CCR1 and CCR3, including macrophages and eosinophils, respectively. Production of CCL5 is induced in response to viral infections, including HIV, rhinoviruses, respiratory syncytial virus (RSV), coronaviruses, and influenza. CCL5 expression positively correlates with disease progression in patients with breast cancer. Cayman's CCL5/RANTES (human, recombinant) protein consists of 69 amino acids and has a calculated molecular weight of 8 kDa.Synonyms: C-C Motif Chemokine Ligand 5, Regulated Upon Activation, Normally T Expressed and Secreted, SIS-delta, T Cell-specific Protein P288, T Cell-specific Protein RANTES, TCP288. Purity: >95% estimated by SDS-PAGE. Source: Recombinant human CCL5 expressed in E. coli. Amino Acids: 24-91. MW: 8 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. Host: E. coli. UniProt Accession #: P13501.
Keywords: | CCL5, EoCP, TCP228, D17S136E, SIS-delta, RANTES(3-68), RANTES(4-68), C-C motif chemokine 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, Eosinophil chemotactic cytokine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32858 |
Properties
Conjugate: | No |
Host: | E. coli |
Purity: | >95% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K12499 | Matching products |
UniProt ID : | P13501 | Matching products |
Gene ID | GeneID 6352 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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