BCA-1/ BLC (CXCL13), human recombinant (rHuBCA-1)

BCA-1/ BLC (CXCL13), human recombinant (rHuBCA-1)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97377.5 5 µg - -

3 - 10 business days*

71.00€
97377.20 20 µg - -

3 - 10 business days*

184.00€
97377.1 1 mg - -

3 - 10 business days*

-
 
Recombinant human CXCL13 produced in E.coli is a single,non-glycosylated, polypeptide chain... more
Product information "BCA-1/ BLC (CXCL13), human recombinant (rHuBCA-1)"

Recombinant human CXCL13 produced in E.coli is a single,non-glycosylated, polypeptide chain containing 87 amino acids and having a molecular mass of 10.3 kDa. BCA-1 is a CXC chemokine that is highly expressed in the secondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt's lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.

Keywords: C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2.
Supplier: Biomol GmbH
Supplier-Nr: 97377.1

Properties

Application: Bioassay
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 10300 D
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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