Activin AB, active, His Tag, human recombinant (rHuActivinAB-His), plant based, bio-clean

Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product contains no animal-derived components or impurities. The biological activity of Activin AB is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation. Activins are homodimers or heterodimers of the various beta subunit isoforms, belonging to the TGFbeta family. Mature Activin AB has two chains of 116 and 123 amino acids residues (betaA-betaB). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Inhibins /Activins are proteins that are formed by the dimerization of two subunits, i. e. an alpha with either betaA -inhibin A- or betaB - inhibin B. The subunits betaA and betaB can also form homodimers or heterodimers called activins. The activin gene family comprises the additional, but poorly characterized members activin betaC, betaD, and betaE.