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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH031986.20 | 20 µg | - |
7 - 16 business days* |
543.00€
|
|||
E-PKSH031986.100 | 100 µg | - |
7 - 16 business days* |
1,102.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse... more
Product information "/ Mouse / Rat / Rhesus / Canine BMP-2 / BMP2A Protein (recombinant human)"
Activity: Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 µg/ml. Protein Construction: A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln283-Arg396) was expressed. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical. Sequence: Gln283-Arg396. Endotoxin: Please contact us for more information. Protein function: BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma. Protein function: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). [The UniProt Consortium]
Keywords: | BMP2, BMP2A, BMP-2, BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A, Recombinant Human / Mouse / Rat / Rhesus / Canine BMP-2 / BMP2A Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH031986 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 13 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K21283 | Matching products |
UniProt ID : | P12643 | Matching products |
Gene ID | GeneID 650 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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