/ Mouse / Rat / Rhesus / Canine BMP-2 Protein (Fc Tag) (recombinant human)

Activity: 1.Measured by its ability to bind recombinant human Nog-Fc in a functional ELISA.2. Measured by its ability to bind recombinant human ALK3-Fch in a functional ELISA.3. Measured by its ability to bind recombinant mouse ALK3-Fch in a functional ELISA.4. Measured by its ability to bind recombinant human BMPR-II-Fc in a functional ELISA. Protein Construction: A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the C-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical. Sequence: Gln 283-Arg 396. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Protein function: BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma. Protein function: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). [The UniProt Consortium]