Proteins and Peptides

5-FAM-Amyloid-beta (1-28) peptide is a fluorescently labeled peptide. Amyloid-beta (1-28) (Abeta28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Abeta42. Abeta28 forms fibrils and plaques in vitro that are similar to those formed by Abeta42 and induces learning deficits in rats. 5-FAM-Amyloid-beta (1-28) is a labeled form of Abeta28...

Biotin-amyloid-beta (1-28) peptide is a biotinylated peptide. Amyloid-beta (1-28) (Abeta28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Abeta42. Abeta28 forms fibrils and plaques in vitro that are similar to those formed by Abeta42 and induces learning deficits in rats. Biotin-amyloid-beta (1-28) peptide is comprised of Abeta28...

Adrenomedullin (11-50) is a truncated form of rat adrenomedullin. Intravenous administration of adrenomedullin (11-50) (3-10 µg/animal) decreases mean systemic arterial pressure in rats in a dose-dependent manner without affecting cardiac output. Cerebroventricular injection of adrenomedullin (11-50) (88 pmol) reduces water intake in response to angiotensin II (Cay-17150),...

Ac-ESMD-CHO is an inhibitor of caspase-3 maturation. It inhibits proteolytic cleavage of the 32 kDa caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site, blocking formation of the p17 caspase-3 active subunit.

Ac-IETD-CHO is an inhibitor of caspase-8 (IC50 = 5 nM). It inhibits fluticasone propionate-induced increases in apoptosis in peripheral blood T-cells isolated from patients with asthma when used at a concentration 60 µM. Ac-IETD-CHO (10 mg/kg) inhibits increases in hepatic caspase-3 activity, DNA fragmentation, cytosolic cytochrome c levels, and proteolytic processing of...

PAMP-20 is an endogenous peptide with hypotensive activity. It consists of the 20 N-terminal amino acids of proadrenomedullin and is found primarily in human adrenal medulla and pheochromocytoma tissue, with small amounts present in the heart, lung, liver, spleen, pancreas, kidney, small intestine, and cerebral cortex. PAMP-20 is an agonist of the G protein-coupled orphan...

Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin (Cay-11694) in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic...

Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. It induces degradation of hypoxia inducible factor 1 alpha (HIF-1alpha) in HEK293 cells and reduces growth in a human renal...

Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons. The amino acid sequence of ACTH (4-10) is common to ACTH and the alpha- and...

TAMRA-Amyloid-beta (1-28) peptide is a fluorescently labeled peptide. Amyloid-beta (1-28) (Abeta28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Abeta42. Abeta28 forms fibrils and plaques in vitro that are similar to those formed by Abeta42 and induces learning deficits in rats. TAMRA-Amyloid-beta (1-28) peptide is a labeled form of...

Bovine Collagen Type I Solution is purified from bovine skin and shown to be 95% pure. Bovine Collagen Type I is one of a family of proteins found particularly in the flesh and connective tissues of mammals (approximately one-third of the body's total protein). Over two dozen types of collagen have been described, Type I is the most abundant form in the body. Collagen Type I...

Recombinant full-length human TRAF2 was expressed by baculovirus in Sf9 insect cells using an N-Terminal his epitope. The purity was determined to be >80% by densitometry. TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily...