Proteins and Peptides

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CBX2 chromodomain (human recombinant)
CBX2 chromodomain (human recombinant)

Item number: Cay14769-100

CBX2 is a component of the polycomb repressive complex 1 and represses protein expression. The chromodomain regions of CBX2 recognizes histone H3 trimethyl lysine 9 (H3K9me3) or trimethyl lysine 27 (H3K27me3). CBX2 knock-out mice have impaired spleen formation, T cell expansion, and inactivation of the X chromosome, which can be lethal in some cases. This protein product...
Application: Binding assays
Expressed in: E.coli
Purity: >90%
Format: Solution
357.00€
Review
L3MBTL1 MBT domains (human recombinant, GST-tagged)
L3MBTL1 MBT domains (human recombinant,...

Item number: Cay14775-100

Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using L3MBTL1 MBT domains (human recombinant, GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor domains, and PWWP-domains. MBT domain-containing proteins have a...
Application: Binding assays
Expressed in: E.coli
Purity: >90% estimated by SDS-PAGE
Format: Solution
357.00€
Review
UHRF1 PHD domain (human recombinant)
UHRF1 PHD domain (human recombinant)

Item number: Cay14777-100

Recognition of epigenetic marks can be mediated by small modular protein units of ~50 amino acids called Plant Homeodomain (PHD) fingers. PHD fingers are zinc binding domains that have a Cys4-His-Cys3 motif and are found in more than 100 nuclear proteins that play a role in regulating chromatin. PHD domains often work with other protein regions, such as bromodomains and...
Application: Binding assays
Expressed in: E.coli
MW: 35,5 kD
Purity: >95%
Format: Solution
357.00€
Review
UHRF1 tudor-like region (human recombinant, His-tagged)
UHRF1 tudor-like region (human recombinant,...

Item number: Cay14779-100

Tudor domains (or tudor-like regions) are small protein structural motifs of ~50 amino acids related to the "Royal Family" of methyl readers, which also includes chromo, malignant brain tumor (MBT), PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell...
Application: Binding assays
Expressed in: E.coli
MW: 31,9 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution
357.00€
Review
HMG-CoA Reductase (human recombinant)
HMG-CoA Reductase (human recombinant)

Item number: Cay14944-250

HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol. HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate....
Application: Enzyme activity
Origin: Human
MW: 76.5 kD
Purity: >90% estimated by SDS-PAGE
Format: Purified
313.00€
Review
eIF4E (human recombinant)
eIF4E (human recombinant)

Item number: Cay15137-100

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA. The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E,...
Application: Binding assays
Expressed in: E.coli
Origin: Human
Purity: >90% estimated by SDS-PAGE
Format: Solution
469.00€
Review
Nicotinamide N-Methyltransferase (human recombinant)
Nicotinamide N-Methyltransferase (human...

Item number: Cay15138-100

Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds. NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has...
Application: Enzyme activity
Purity: >95% estimated by SDS-PAGE
Format: Solution
313.00€
Review
STING (SUMO-tagged, H232 variant, human recombinant)
STING (SUMO-tagged, H232 variant, human...

Item number: Cay15139-50

Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers. Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). Loss of STING regulation contributes to...
Application: Binding assays
Expressed in: E.coli
MW: 34,5 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution
494.00€
Review
CBX3 (human recombinant)
CBX3 (human recombinant)

Item number: Cay15467-100

The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-alpha (CBX5), HP1-beta (CBX1), and HP1-gamma (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation. CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two. Extensive post-translational...
Application: Binding assays
Expressed in: E.coli
Origin: Human
Purity: >95% (estimated by SDS-PAGE)
Format: Solution
357.00€
Review
Catechol O-Methyltransferase (human recombinant)
Catechol O-Methyltransferase (human recombinant)

Item number: Cay15563-100

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens, ascorbic acid, and...
Application: Enzyme activity
Origin: Human
MW: 37.6 kD
Purity: >70% estimated by SDS-PAGE
Format: Solution
407.00€
Review
eIF4E (human recombinant, GST-tagged)
eIF4E (human recombinant, GST-tagged)

Item number: Cay15564-100

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA. The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E,...
Expressed in: E.coli
Origin: Human
Purity: >85%
Format: Solution
469.00€
Review
(Glp1)-Apelin-13
(Glp1)-Apelin-13

Item number: Cay15590-1

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Cay-13524), apelin-17, and apelin-13 (Cay-13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. (Glp1)-Apelin-13 is a pyroglutamylated...
Application: APLNR / APJ receptor ligand
CAS 217082-60-5
MW: 1533.8 D
Purity: >95%
Format: Solid
137.00€
Review
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