DEPDC5 (Vector pENTR223.1, Accession No. BC057797)

Length: 1680 Sequence: atgagaacaa caaaggtcta caaactcgtc atccacaaga agggctttgg gggcagtgat gatgagctag ttgtgaaccc caaagtgttc cctcacatca agcttggaga cattgtagag attgcacacc ccaacgatga atacagccct ctgcttttgc aggtcaagtc tcttaaggaa gatttacaga aggaaactat cagtgtggac cagactgtga ctcaagtgtt ccggctgaga ccttatcagg atgtctatgt taatgtcgta gaccctaagg atgtgaccct tgacctagtg gaattaactt ttaaggatca gtatattggc cgtggggata tgtggcgact aaagaaaagt ttggtcagca catgtgccta tatcacccag aaggtggagt ttgctggcat cagagcacag gctggtgaac tgtgggttaa gaatgagaag gtcatgtgtg gctacatcag tgaagatacc agggtggtgt ttcgttctac gtcggctatg gtttacatat ttattcagat gagctgtgaa atgtgggatt ttgatattta tggggatttg tattttgaga aagctgtgaa tggtttcctt gctgatctat ttaccaagtg gaaggagaag aactgtagtc atgaagtgac agtggtcctg ttttctagaa ctttctatga tgcaaaatct gttgatgaat ttcctgaaat aaaccgagcc tcaattcgac aggatcacaa ggggagattc tatgaagact tttacaaagt ggtggtgcag aatgagagaa gagaagaatg gacttcactt ctcgtaacca ttaaaaaact cttcatccag tatccagtgt tggtgcgact ggaacaggca gagggctttc ctcaaggaga taattctacc tcagcacaag gaaactacct ggaggccatc aatctgtcat tcaatgtgtt tgataagcac tacatcaacc gcaactttga ccgaactggg cagatgtcag tggtgatcac gcccggggtg ggtgtctttg aagtggaccg cctactcatg atcctgacca agcagcggat gatagataat ggaattggtg tggatttggt gtgcatggga gagcaaccgt tacatgctgt cccattgttc aagctccata atcggagtgc tccccgtgat tctcgtctgg gcgatgacta taatatccct cactggataa accacagttt ctacacatcc aaaagccagc tcttttgtaa tagtttcacc ccacgaataa aactggcagg aaagaagccc gcctctgaga aagcaaaaaa tggccgtgat acatctctcg ggagtccaaa agaatctgag aacgcccttc ccatccaagt agattatgac gcctatgacg ctcaagtgtt caggctgccc ggcccatccc gggcccagtg cctcaccacc tgcagatctg tgcgagagcg agagagtcac agtcgaaaga gtgccagctc ctgtgatgtt tcatccagcc cttccctacc aagccgcaca ctgcccactg aggaagtgag gagccaggct tctgacgaca gctccctagg caagagtgcc aacatcctga tgatcccaca cccccacctg caccagtatg aagtcagcag ctccttggga tacaccagca ctcgagagca Protein function: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. [The UniProt Consortium]