DAD1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 342 Sequence: atgtcggcgt cggtagtgtc tgtcatttcg cggttcttag aagagtactt gagctccatt ccgcagcgtc tgaagttgct ggacgcgtac ctgctgtata tactgctgac cggggcgctg cagttcggtt actgtctcct cgtggggacc ttccccttca actcttttct ctcgggcttc atctcttgtg tggggagttt catcctagcg gtttgcctga gaatacagat caacccacag aacaaagcgg atttccaagg catctcccca gagcgagcct ttgctgattt tctctttgcc agcaccatcc tgcaccttgt tgtcatgaac tttgttggct Protein function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853). [The UniProt Consortium]