CCRN4L (Vector pUC, Accession No. BC113494)

Length: 1296 Sequence: atgtttcata gtccgcggcg gctctgctcg gccctgctgc agagggacgc gcccggcctg cgccgcctgc ccgccccagg gctgcgccgc ccgttgtccc cgccggctgc tgttcccagg cccgcatccc cccggctgct ggcggcggcc tcggcggcct cgggcgccgc gaggtcgtgt tcccgaacag tgtgttccat gggaaccggt acaagcagac tctatagtgc tctcgccaag acactgaaca gcagcgctgc ctcccagcac ccagagtatt tggtgtcacc tgacccagag catctggagc ccattgatcc taaagagctt cttgaggaat gcagggccgt cctgcacacc cgacctcccc ggttccagag ggattttgtg gatctgagga cagattgccc tagtacccac ccacctatca gggttatgca atggaacatc ctcgcccaag ctcttggaga aggcaaagac aactttgtac agtgccctgt tgaagcactc aaatgggaag aaaggaaatg tctcatcctg gaagaaatcc tggcctacca gcctgatata ttgtgcctcc aagaggtgga ccactatttt gacaccttcc agccactcct cagtagacta ggctatcaag gcacgttttt ccccaaaccc tggtcacctt gtctagatgt agaacacaac aatggaccag atggttgtgc cttatttttt cttcaaaacc gattcaagct agtcaacagt gccaatatta ggctgacagc catgacattg aaaaccaacc aggtggccat tgcacagacc ctggagtgca aggagtcagg ccgacagttc tgcatcgctg ttacccatct aaaagcacgc actggctggg agcggtttcg atcagctcaa ggctgtgacc tccttcagaa cctgcaaaac atcacccaag gagccaagat tccccttatt gtgtgtgggg acttcaatgc agagccaaca gaagaggtct acaaacactt tgcttcctcc agcctcaacc tgaacagcgc ctacaagctg ctgagtgctg atgggcagtc agaaccccca tacactacct ggaagatccg gacctcaggg gagtgcaggc acaccctgga ttacatctgg tattctaaac atgctctaaa tgtaaggtca gctctcgatc tgctcactga agaacagatt ggacccaaca ggttaccttc cttcaattat ccttcagacc acctgtctct agtgtgtgac ttcagcttta ctgaggaatc tgatggactt Protein function: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos. [The UniProt Consortium]