ARHGAP17 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 2646 Sequence: atgaagaagc agttcaaccg catgaagcag ctggctaacc agaccgtggg cagagctgag aaaacagaag tccttagtga agatctatta cagattgaga gacgcctgga cacggtgcgg tcaatatgcc accattccca taagcgcttg gtggcatgtt tccagggcca gcatggcacc gatgccgaga ggagacacaa aaaactgcct ctgacagctc ttgctcaaaa tatgcaagaa gcatcgactc agctggaaga ctctctcctg gggaagatgc tggagacgtg tggagatgct gagaatcagc tggctctcga gctctcccag cacgaagtct ttgttgagaa ggagatcgtg gaccctctgt acggcatagc tgaggtggag attcccaaca tccagaagca gaggaagcag cttgcaagat tggtgttaga ctgggattca gtcagagcca ggtggaacca agctcacaaa tcctcaggaa ccaactttca ggggcttcca tcaaaaatag atactctaaa ggaagagatg gatgaagctg gaaataaagt agaacagtgc aaggatcaac ttgcagcaga catgtacaac tttatggcca aagaagggga gtatggcaaa ttctttgtta cgttattaga agcccaagca gattaccata gaaaagcatt agcagtctta gaaaagaccc tccccgaaat gcgagcccat caagataagt gggcggaaaa accagccttt gggactcccc tagaagaaca cctgaagagg agcgggcgcg agattgcgct gcccattgaa gcctgtgtca tgctgcttct ggagacaggc atgaaggagg agggcctttt ccgaattggg gctggggcct ccaagttaaa gaagctgaaa gctgctttgg actgttctac ttctcacctg gatgagttct attcagaccc ccatgctgta gcaggtgctt taaaatccta tttacgggaa ttgcctgaac ctttgatgac ttttaatctg tatgaagaat ggacacaagt tgcaagtgtg caggatcaag acaaaaaact tcaagacttg tggagaacat gtcagaagtt gccaccacaa aattttgtta actttagata tttgatcaag ttccttgcaa agcttgctca gaccagcgat gtgaataaaa tgactcccag caacattgcg attgtgttag gccctaactt gttatgggcc agaaatgaag gaacacttgc tgaaatggca gcagccacat ccgtccatgt ggttgcagtg attgaaccca tcattcagca tgccgactgg ttcttccctg aagaggtgga atttaatgta tcagaagcat ttgtacctct caccaccccg agttctaatc actcattcca cactggaaac gactctgact cggggaccct ggagaggaag cggcctgcta gcatggcggt gatggaagga gacttggtga agaaggaaag ctttggtgtg aagcttatgg acttccaggc ccaccggcgg ggtggcactc taaatagaaa gcacatatcc cccgctttcc agccgccact tccgcccaca gatggcagca ccgtggtgcc cgctggccca gagccccctc cccagagctc tagggctgaa agcagctctg ggggtgggac tgtcccctct tccgcgggca tactggagca ggggccgagc ccaggcgacg gcagtcctcc caaaccgaag gaccctgtat ctgcagctgt gccagcacca gggagaaaca acagtcagat agcatctggc caaaatcagc cccaggcagc tgctggctcc caccagctct ccatgggcca acctcacaat gctgcagggc ccagcccgca tacactgcgc cgagctgtta aaaaacccgc tccagcaccc ccgaaaccgg gcaacccacc tcctggccac cccgggggcc agagttcttc aggaacatct cagcatccac ccagtctgtc accaaagcca cccacccgaa gcccctctcc tcccacccag cacacgggcc agcctccagg ccagccctcc gccccctccc agctctcagc accccggagg tactccagca gcttgtctcc aatccaagct cccaatcacc caccgccgca gccccctacg caggccacgc cactgatgca caccaaaccc aatagccagg gccctcccaa ccccatggca ttgcccagtg agcatggact tgagcagcca tctcacaccc ctccccagac tccaacgccc cccagtactc cgcccctagg aaaacagaac cccagtctgc cagctcctca gaccctggca gggggtaacc ctgaaactgc acagccacat gctggaacct taccgagacc gagaccagta ccaaagccaa ggaaccggcc cagcgtgccc ccaccccccc aacctcctgg tgtccactca gctggggaca gcagcctcac caacacagca ccaacagctt ccaagatagt aacagactcc aattccaggg tttcagaacc gcatcgcagc atctttcctg aaatgcactc agactcagcc agcaaagacg tgcctggccg catcctgctg gatatagaca atgataccga gagcactgcc Protein function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. [The UniProt Consortium]