Oleoyl Ethanolamide-d4

Oleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1',2, and 2' positions. It is intended for use as an internal standard for the quantification of oleoyl ethanolamide by GC- or LC-mass spectrometry. Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue, but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous, potent agonist for PPARalpha, exhibiting an EC50 value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARalpha wild-type mice, but not in PPARalpha knockout mice. These data indicate that OEA regulates food intake by a PPARalpha-mediated mechanism.Formal Name: N-(2-hydroxyethyl-1',1,2,2'-d4)-9Z-octadecenamide. CAS Number: 946524-36-3. Synonyms: OEA-d4, Oleic Acid Ethanolamide-d4. Molecular Formula: C20H35D4NO2. Formula Weight: 329.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 100 µg/ml. SMILES: CCCCCCCC\C=C/CCCCCCCC(N([H])C([2H])([2H])C([2H])([2H])O)=O. InChi Code: InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-/i18D2,19D2. InChi Key: BOWVQLFMWHZBEF-QAFBOUAWSA-N.