Withanolide B

Withanolide B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11798-1 1 mg -

6 - 10 business days*

109.00€
Cay11798-5 5 mg -

6 - 10 business days*

399.00€
Cay11798-10 10 mg -

6 - 10 business days*

583.00€
 
Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does... more
Product information "Withanolide B"
Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor (Ki = 5.15 nM), that also inhibited inducible NOS (iNOS) and endothelial NOS (eNOS, Kis = 15.48 and 66.59 nM, respectively), and as a ligand for the PARP1 catalytic domain with an estimated Ki value of 7.54 nM.Formal Name: 6alpha,7alpha-epoxy-5alpha,22R-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, delta-lactone. CAS Number: 56973-41-2. Molecular Formula: C28H38O5. Formula Weight: 454.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 0.1 mg/ml, Methanol: 0.5 mg/ml. lambdamax: 225 nm. SMILES: O=C1[C@@]2(C)[C@]([C@@H](O3)[C@@H]3[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@H]5[C@H](C)[C@@]6(OC(C(C)=C(C)C6)=O)[H])(O)CC=C1. InChi Code: InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23-,24-,26+,27-,28-/m0/s1. InChi Key: ZTEVDTFJUUJBLP-MBMSZCMESA-N. Origin: Plant/Withania somnifera.
Keywords: 6alpha,7alpha-epoxy-5alpha,22R-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, delta-lactone
Supplier: Cayman Chemical
Supplier-Nr: 11798

Properties

Application: NOS inhibitor, PARP1 catalytic domain ligand
MW: 454.6 D
Formula: C28H38O5
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 56973-41-2| Matching products
KEGG ID : K13240 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
H Phrases: H413
P Phrases: P273, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Withanolide B"
Write a review
or to review a product.
Viewed