Unoprostone isopropyl ester

Unoprostone isopropyl ester is an ocular hypotensive agent, a prodrug form of the FP receptor agonist unoprostone (Cay-16680), and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It inhibits contractions induced by the peptide vasoconstrictor endothelin-1 (Cay-24127) in isolated porcine retinal arterioles when used at a concentration of 1 nM. Topical application of unoprostone isopropyl ester (0.12% v/v) inhibits increased intraocular pressure induced by the non-selective COX inhibitor indomethacin (Cay-70270) and increases PGE2 levels in the aqueous humor and aqueous humor outflow in rabbits. Formulations containing unoprostone isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.Formal Name: 9alpha,11alpha-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester. CAS Number: 120373-24-2. Synonyms: 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2alpha isopropyl ester, UF-021. Molecular Formula: C25H44O5. Formula Weight: 424.6. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 1 mg/ml, Ethanol: 15 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1. InChi Key: XXUPXHKCPIKWLR-JHUOEJJVSA-N.