Unoprostone isopropyl ester

Unoprostone isopropyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16681-1 1 mg -

6 - 10 business days*

Cay16681-5 5 mg -

6 - 10 business days*

Cay16681-10 10 mg -

6 - 10 business days*

Cay16681-50 50 mg -

6 - 10 business days*

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone,... more
Product information "Unoprostone isopropyl ester"
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2alpha (PGF2alpha). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2alpha are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2alpha on FP receptors. Formal Name: 9alpha,11alpha-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester. CAS Number: 120373-24-2. Synonyms: 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2alpha isopropyl ester, Rescula. Molecular Formula: C25H44O5. Formula Weight: 424.6. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 17 mg/ml, Ethanol: 17 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1. InChi Key: XXUPXHKCPIKWLR-JHUOEJJVSA-N.
Keywords: 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2alpha isopropyl ester, Rescula, 9alpha,11alpha-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester
Supplier: Cayman Chemical
Supplier-Nr: 16681


Application: Bioactive lipid assays
MW: 424.6 D
Formula: C25H44O5
Purity: >95%
Format: Solution

Database Information

CAS : 120373-24-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H302, H316, H319, H336, H360
P Phrases: , P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+310, P303+361+353, P304+340, P305+351+338, P308+313, P312, P330, P332+313, P337+313, P370+378, P403+233, P403+235, P405, P501
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